Novel estradiol derivative, its preparation, and antitumor agent

  • Inventors:
  • Assignees: Kureha Chem Ind Co Ltd
  • Publication Date: July 05, 1980
  • Publication Number: JP-S5589299-A

Abstract

NEW MATERIAL:3-Acyloxy-1,3,5(10)-estratriene-17β-[ 4-{P-[ bis(2-chloroethyl) amino ]phenyl}butanoyloxy ] acetate shown by the formula I (R is an acyl shown by the formula II, III, IV and V. USE: An antitumor agent for uterine cancer, carcer of the breast, prostatic cancer, and caner of the thyriod gland. PROCESS: The hydroxyl group at 3-position of 3-hydroxy-1,3,5(10)-estratriene-17β- [ 4-{P-[bis(2-chlorolthyl)amyno]phenyl}butanoyloxy ] acetate is replaced by acyloxy group to give the desired compound shown by the formula I. COPYRIGHT: (C)1980,JPO&Japio

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    JP-S6426595-AJanuary 27, 1989Kureha Chemical Ind Co LtdInjection containing estradiol derivative